Phenotypes Associated with This Genotype

Genotype
MGI:5319195

• Allelic Composition: Fkbp1a^tm1.1Shou/Fkbp1a^tm1.1Shou; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart electrocardiography waveform feature ( J:183588 )

• shorter PP interval

• significant acceleration of the maximal phase 0 upstroke velocity in the left ventricle

abnormal myocardial fiber physiology ( J:183588 )

• mean peak macroscopic voltage-gated Na+ current densities are increased more than 2 fold in ventricular cardiomyocytes

• acceleration of both the early and late component of voltage-gated Na+ current inactivation in ventricular cardiomyocytes

muscle

abnormal myocardial fiber physiology ( J:183588 )

• mean peak macroscopic voltage-gated Na+ current densities are increased more than 2 fold in ventricular cardiomyocytes

• acceleration of both the early and late component of voltage-gated Na+ current inactivation in ventricular cardiomyocytes