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Phenotypes Associated with This Genotype
Genotype
MGI:5318976
Allelic
Composition
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
Genetic
Background
B6.Cg-Mapttm1(Mecp2)Jae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(Mecp2)Jae mutation (1 available); any Mapt mutation (425 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

nervous system
• high frequency stimulation-induced long term potentiation is attenuated in hippocampal slices from mutants compared to wild-type mice
• hippocampal neurons exhibit enhanced miniature excitatory neurotransmission; hippocampal neurons show an increase in mEPSC frequency with no change in mEPSC amplitude
• paired-pulse facilitation is augmented in mutants at the interstimulus intervals of 30 and 50 ms

behavior/neurological
• mutants display consistent freezing levels across all extinction trials, indicating impaired extinction learning
• mutants exhibit an increase in freezing behavior in context (novel environment)-dependent fear conditioning 24 hours after training, suggesting enhanced associative learning
• mutants exhibit an increase in freezing behavior in cue (auditory tone)-dependent fear conditioning 24 hours after training, suggesting enhanced associative learning
• however, mutants are incapable of extinguishing their conditioned response (freezing) to cue when cue is presented alone (without shock), indicating severe impairments in extinction learning and associative learning
• mutants do not show enhanced freezing behavior in the absence of a paired stimulus (baseline freezing) or before the tone in cued fear conditioning, suggesting that mutants learn to associate the cue with the shock
• in the NOR task to test ability to recognize a novel object, mutants spend less time with the novel object than wild-type mice and show less preference for the novel object over the familiar indicating impaired episodic memory
• in the elevated plus maze, mutants spend less time in the center, more time in the closed arms, and less time in the open arms compared with wild-type
• in the dark/light test, mutants spend less time in the light side and more time in the dark side, indicating heightened anxiety
• mutants spend less time on the rotarod than wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
syndromic X-linked intellectual disability Lubs type DOID:0060799 OMIM:300260
J:182685


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory