Phenotypes Associated with This Genotype

Genotype
MGI:5318693

• Allelic Composition: Chrnb2^tm1Jpc/Chrnb2^tm1Jpc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:103908 )

N • IgM levels of preimmune serum are little altered from control levels

decreased B cell number ( J:103908 )

• number of IgG secreting cells is reduced

abnormal immune system physiology ( J:103908 )

increased B cell proliferation ( J:103908 )

• elevated proliferation in response to antiCD40 which is inhibited by nicotine

abnormal immunoglobulin level ( J:103908 )

increased IgG level ( J:103908 )

• increased IgG response to cytochrome c

• level remains elevated for 6 months after primary immunization

decreased immunoglobulin level ( J:103908 )

• significantly reduced preimmune serum Ig levels

hematopoietic system

increased B cell proliferation ( J:103908 )

• elevated proliferation in response to antiCD40 which is inhibited by nicotine

decreased B cell number ( J:103908 )

• number of IgG secreting cells is reduced

abnormal immunoglobulin level ( J:103908 )

increased IgG level ( J:103908 )

• increased IgG response to cytochrome c

• level remains elevated for 6 months after primary immunization

decreased immunoglobulin level ( J:103908 )

• significantly reduced preimmune serum Ig levels

cellular

increased B cell proliferation ( J:103908 )

• elevated proliferation in response to antiCD40 which is inhibited by nicotine