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Phenotypes Associated with This Genotype
Genotype
MGI:5318542
Allelic
Composition
Slc12a6tm1Garo/Slc12a6tm1Garo
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a6tm1Garo mutation (1 available); any Slc12a6 mutation (83 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• unable to successfully breed (J:183239)
• unable to successfully breed (J:183239)

nervous system
• progressive peripheral neuropathy starting at 3-4 weeks of age (J:183239)
• progressive peripheral neuropathy starting at 3-4 weeks of age (J:183239)
• at 2 months of age (J:183239)
• at 2 months of age (J:183239)
• hypoplastic with a small but significant decrease in length (J:183239)
• hypoplastic with a small but significant decrease in length (J:183239)
• axon swelling in sciatic nerves (J:183239)
• axon swelling in sciatic nerves (J:183239)
• axon degeneration, hypomyelination and axon swelling in sciatic nerves (J:183239)
• axon degeneration, hypomyelination and axon swelling in sciatic nerves (J:183239)
• in sciatic nerves (J:183239)
• in sciatic nerves (J:183239)
• hypomyelination in sciatic nerves (J:183239)
• hypomyelination in sciatic nerves (J:183239)

behavior/neurological
• by 3-4 weeks of age (J:183239)
• by 3-4 weeks of age (J:183239)
• severe locomotor deficiencies (J:183239)
• deficiencies become more severe after 8 months of age (J:183239)
• severe locomotor deficiencies (J:183239)
• deficiencies become more severe after 8 months of age (J:183239)
• significant increase in the total distance traveled and the number of movement bouts at 5 months of age (J:183239)
• significant increase in the total distance traveled and the number of movement bouts at 5 months of age (J:183239)
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain (J:183239)
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain (J:183239)

growth/size/body
• at 2 months of age (J:183239)
• at 2 months of age (J:183239)

integument
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain (J:183239)
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain (J:183239)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory