Mouse Genome Informatics
cn
    Slc12a6tm1Garo/Slc12a6tm1Garo
Tg(Syn1-cre)671Jxm/0

involves: 129 * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
reproductive system
• unable to successfully breed

nervous system
• progressive peripheral neuropathy starting at 3-4 weeks of age
• at 2 months of age
• hypoplastic with a small but significant decrease in length
• axon swelling in sciatic nerves
• axon degeneration, hypomyelination and axon swelling in sciatic nerves
• in sciatic nerves
• hypomyelination in sciatic nerves

behavior/neurological
• by 3-4 weeks of age
• severe locomotor deficiencies
• deficiencies become more severe after 8 months of age
• significant increase in the total distance traveled and the number of movement bouts at 5 months of age
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain

growth/size
• at 2 months of age

integument
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain

Mouse Models of Human Disease
OMIM IDRef(s)
Agenesis of the Corpus Callosum with Peripheral Neuropathy; ACCPN 218000 J:183239