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Phenotypes Associated with This Genotype
Genotype
MGI:5318542
Allelic
Composition
Slc12a6tm1Garo/Slc12a6tm1Garo
Tg(Syn1-cre)671Jxm/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc12a6tm1Garo mutation (1 available); any Slc12a6 mutation (86 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• unable to successfully breed

nervous system
• progressive peripheral neuropathy starting at 3-4 weeks of age
• at 2 months of age
• hypoplastic with a small but significant decrease in length
• axon swelling in sciatic nerves
• axon degeneration, hypomyelination and axon swelling in sciatic nerves
• in sciatic nerves
• hypomyelination in sciatic nerves

behavior/neurological
• by 3-4 weeks of age
• severe locomotor deficiencies
• deficiencies become more severe after 8 months of age
• significant increase in the total distance traveled and the number of movement bouts at 5 months of age
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain

growth/size/body
• at 2 months of age

integument
• significantly less sensitive in a formalin test of spontaneous chemical/inflammatory pain


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory