Phenotypes Associated with This Genotype

Genotype
MGI:5318400

• Allelic Composition: Epcam^tm1.1Mcu/Epcam^tm1.1Mcu; Tg(CD207-cre)1Dhka/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal Langerhans cell morphology ( J:182665 )

• about a 2 fold increase in frequency in epidermal sheets compared to wild-type controls

• cells are larger and have longer, more delicate dendrites

abnormal Langerhans cell physiology ( J:182665 )

• impaired migration of Langerhans cells from skin explants

• at 36 h, but not at 18 or 48 h, after application of TNCB to the ear skin the number of activated Langerhans cells is increased about 2 fold indicating a defect in the ability of these cells to exit the epidermis

• strikingly fewer Langerhans cells are found in the skin draining lymph nodes at 96 and 120 h after hapten application

increased susceptibility to type IV hypersensitivity reaction ( J:182665 )

• ear swelling is increased about 2 fold and the duration of the response is prolonged following treatment and challenge with 2,4-dinitrofluorobenzene

hematopoietic system

abnormal Langerhans cell morphology ( J:182665 )

• about a 2 fold increase in frequency in epidermal sheets compared to wild-type controls

• cells are larger and have longer, more delicate dendrites

cellular

abnormal cell migration ( J:182665 )

• impaired migration of Langerhans cells from skin explants

• at 36 h, but not at 18 or 48 h, after application of TNCB to the ear skin the number of activated Langerhans cells is increased about 2 fold indicating a defect in the ability of these cells to exit the epidermis

• strikingly fewer Langerhans cells are found in the skin draining lymph nodes at 96 and 120 h after hapten application