Phenotypes Associated with This Genotype

Genotype
MGI:5318195

• Allelic Composition: Nrg1^tm1Gne/Nrg1⁺
• Genetic Background: B6.129S2-Nrg1^tm1Gne

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal excitatory postsynaptic currents ( J:182690 )

• EPSCs remain elevated following theta-pulse stimulation (TPS) and slowly run down whereas in wild-type slices, LTP reversal is triggered by TPS

enhanced long-term potentiation ( J:182690 )

• significantly increased compared to controls (EPSC amplitude 322% vs 157%)

• after LTP induction, extended period of enhanced LTP is followed by a period of decreasing LTP