Mouse Genome Informatics
hm
    Lgi1tm1.1Ics/Lgi1tm1.1Ics
involves: 129S2/SvPas * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• spontaneous beginning in the second postnatal week (P10), especially during cage changing and handling
• during cage changing and handling
• mossy fibers in temporal lobe epilepsies often sprout aberrant recurrent synapses with dentate granule cells
• abnormal dispersion at P14 after the onset of seizures
• mossy fibers in temporal lobe epilepsies often sprout aberrant recurrent synapses with dentate granule cells
• at P14 after the onset of seizures, particularly in the hilus of the dentate gyrus
• mice exhibit ictal epileptic electroencephalogram abnormalities, often bilateral, compared with wild-type mice
• following the onset of seizures

growth/size
• lack of body fact at P14
• between P10 and P14

behavior/neurological
• mice lack stomach contents at death and likely die of dehydration and/or starvation
• inactive by P14
• spontaneous beginning in the second postnatal week (P10), especially during cage changing and handling
• during cage changing and handling

adipose tissue
• lack of body fact at P14

mortality/aging
• mean lifetime of 16 days; no mice survive beyond P21
• mice lack stomach contents at death and likely die of dehydration and/or starvation

Mouse Models of Human Disease
OMIM IDRef(s)
Epilepsy, Familial Temporal Lobe, 1; ETL1 600512 J:182795