About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5317116
Allelic
Composition
Lgi1tm1.1Ics/Lgi1tm1.1Ics
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1tm1.1Ics mutation (0 available); any Lgi1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• spontaneous beginning in the second postnatal week (P10), especially during cage changing and handling (J:182795)
• spontaneous beginning in the second postnatal week (P10), especially during cage changing and handling (J:182795)
• during cage changing and handling (J:182795)
• during cage changing and handling (J:182795)
• increased thickness (J:182795)
• increased thickness (J:182795)
• mossy fibers in temporal lobe epilepsies often sprout aberrant recurrent synapses with dentate granule cells (J:182795)
• mossy fibers in temporal lobe epilepsies often sprout aberrant recurrent synapses with dentate granule cells (J:182795)
• abnormal dispersion at P14 after the onset of seizures (J:182795)
• mossy fibers in temporal lobe epilepsies often sprout aberrant recurrent synapses with dentate granule cells (J:182795)
• abnormal dispersion at P14 after the onset of seizures (J:182795)
• mossy fibers in temporal lobe epilepsies often sprout aberrant recurrent synapses with dentate granule cells (J:182795)
• at P14 after the onset of seizures, particularly in the hilus of the dentate gyrus (J:182795)
• at P14 after the onset of seizures, particularly in the hilus of the dentate gyrus (J:182795)
• following the onset of seizures (J:182795)
• following the onset of seizures (J:182795)
• mice exhibit ictal epileptic electroencephalogram abnormalities, often bilateral, compared with wild-type mice (J:182795)
• mice exhibit ictal epileptic electroencephalogram abnormalities, often bilateral, compared with wild-type mice (J:182795)

growth/size/body
• lack of body fact at P14 (J:182795)
• lack of body fact at P14 (J:182795)
• at P14 (J:182795)
• at P14 (J:182795)
• at P14 (J:182795)
• at P14 (J:182795)
• between P10 and P14 (J:182795)
• between P10 and P14 (J:182795)

behavior/neurological
• mice lack stomach contents at death and likely die of dehydration and/or starvation (J:182795)
• mice lack stomach contents at death and likely die of dehydration and/or starvation (J:182795)
• inactive by P14 (J:182795)
• inactive by P14 (J:182795)
• spontaneous beginning in the second postnatal week (P10), especially during cage changing and handling (J:182795)
• spontaneous beginning in the second postnatal week (P10), especially during cage changing and handling (J:182795)
• during cage changing and handling (J:182795)
• during cage changing and handling (J:182795)

adipose tissue
• lack of body fact at P14 (J:182795)
• lack of body fact at P14 (J:182795)

mortality/aging
• mean lifetime of 16 days; no mice survive beyond P21 (J:182795)
• mice lack stomach contents at death and likely die of dehydration and/or starvation (J:182795)
• mean lifetime of 16 days; no mice survive beyond P21 (J:182795)
• mice lack stomach contents at death and likely die of dehydration and/or starvation (J:182795)

Mouse Models of Human Disease
OMIM ID Ref(s)
Epilepsy, Familial Temporal Lobe, 1; ETL1 600512 J:182795


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory