Phenotypes Associated with This Genotype

Genotype
MGI:5316663

• Allelic Composition: Col1a1^{tm1(tetO-YAP1*)Fcam}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:141457 )

• mice become ill and must be euthanized 4-6 days after doxycycline treatment

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:141457 )

• mature goblet cells are absent 5 days after doxycycline treatment

• however, the absence of mature goblet cells is reversed by doxycycline-withdrawal and administration of dipenzazepine increased goblet cell numbers

abnormal enterocyte proliferation ( J:141457 )

• increased proliferation of epithelium cells in the crypt regions, villus regions and at the tip of the villi of undifferentiated progenitor cells in doxycycline-treated mice

• dipenzazepine administration decreases cell proliferation in the intestine of mice treated with doxycycline

• however, proliferation of undifferentiated cells is reversed by doxycycline-withdrawal

increased pancreatic acinar cell number ( J:141457 )

• in doxycycline-treated mice

abnormal intestinal epithelium morphology ( J:141457 )

• severe dysplasia in doxycycline-treated mice

absent Paneth cells ( J:141457 )

• Paneth cells are absent 5 days after doxycycline treatment

• however, the absence of Paneth cells is reversed by doxycycline-withdrawal

endocrine/exocrine glands

increased pancreatic acinar cell number ( J:141457 )

• in doxycycline-treated mice

absent Paneth cells ( J:141457 )

• Paneth cells are absent 5 days after doxycycline treatment

• however, the absence of Paneth cells is reversed by doxycycline-withdrawal

enlarged pancreas ( J:141457 )

• in doxycycline-treated mice

pancreatic acinar-to-ductal metaplasia ( J:141457 )

• ductal metaplasia of pancreatic acinar cells in doxycycline-treated mice

cellular

abnormal intestinal goblet cell morphology ( J:141457 )

• mature goblet cells are absent 5 days after doxycycline treatment

• however, the absence of mature goblet cells is reversed by doxycycline-withdrawal and administration of dipenzazepine increased goblet cell numbers

abnormal enterocyte proliferation ( J:141457 )

• increased proliferation of epithelium cells in the crypt regions, villus regions and at the tip of the villi of undifferentiated progenitor cells in doxycycline-treated mice

• dipenzazepine administration decreases cell proliferation in the intestine of mice treated with doxycycline

• however, proliferation of undifferentiated cells is reversed by doxycycline-withdrawal

increased cell proliferation ( J:141457 )

• in the epidermis of doxycycline-treated mice

homeostasis/metabolism

decreased alkaline phosphatase activity ( J:141457 )

• absent in the small intestine 5 days after doxycycline treatment

integument

thick skin ( J:141457 )

• in doxycycline-treated mice

growth/size/body

enlarged pancreas ( J:141457 )

• in doxycycline-treated mice