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Phenotypes Associated with This Genotype
Genotype
MGI:5316488
Allelic
Composition
Ext1tm1Yama/Ext1tm1Yama
Tg(Camk2a-cre)2834Lusc/0
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1Yama mutation (0 available); any Ext1 mutation (20 available)
Tg(Camk2a-cre)2834Lusc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the elevated plus maze, mutants spend more than half the session time on the open arms and moved freely on them compared to wild-type mice that remain mostly on the closed arms, indicating reduced fear of height (J:182220)
• in the light/dark box text, mutants spent more time in the brightly illuminated space than wild-type mice, although the number of transitions between light and dark spaces did not differ (J:182220)
• in the open-field test, mutants spend a longer time in the central area than wild-type mice and exhibit higher levels of locomotor activity, indicating reduced fear of open spaces (J:182220)
• in the elevated plus maze, mutants spend more than half the session time on the open arms and moved freely on them compared to wild-type mice that remain mostly on the closed arms, indicating reduced fear of height (J:182220)
• in the light/dark box text, mutants spent more time in the brightly illuminated space than wild-type mice, although the number of transitions between light and dark spaces did not differ (J:182220)
• in the open-field test, mutants spend a longer time in the central area than wild-type mice and exhibit higher levels of locomotor activity, indicating reduced fear of open spaces (J:182220)
• in the elevated plus maze, mutants spend more than half the session time on the open arms and moved freely on them compared to wild-type mice that remain mostly on the closed arms, indicating reduced fear of height (J:182220)
• in the light/dark box text, mutants spent more time in the brightly illuminated space than wild-type mice, although the number of transitions between light and dark spaces did not differ (J:182220)
• in the open-field test, mutants spend a longer time in the central area than wild-type mice and exhibit higher levels of locomotor activity, indicating reduced fear of open spaces (J:182220)
• in the elevated plus maze, mutants spend more than half the session time on the open arms and moved freely on them compared to wild-type mice that remain mostly on the closed arms, indicating reduced fear of height (J:182220)
• in the light/dark box text, mutants spent more time in the brightly illuminated space than wild-type mice, although the number of transitions between light and dark spaces did not differ (J:182220)
• in the open-field test, mutants spend a longer time in the central area than wild-type mice and exhibit higher levels of locomotor activity, indicating reduced fear of open spaces (J:182220)
• in the open-field test, mutants exhibit higher levels of locomotor activity (J:182220)
• in the open-field test, mutants exhibit higher levels of locomotor activity (J:182220)
• in the hole-board test, while wild-type mice explore different holes in a random or successive manner, mutants show a tendency towards making repeated head-dips into the same hole, indicating stereotyped dip behavior; occurrence of stereotypic dip was significantly greater, however the total number of head-dips did not differ from wild-type (J:182220)
• mutants show a tendency to perform consecutive head-dips of more than 4 repetitions, a behavior not seen in wild-type mice (J:182220)
• however, mutants do not exhibit spontaneous stereotypic behavior such as jumping, circling, paw flapping or self-grooming (J:182220)
• in the hole-board test, while wild-type mice explore different holes in a random or successive manner, mutants show a tendency towards making repeated head-dips into the same hole, indicating stereotyped dip behavior; occurrence of stereotypic dip was significantly greater, however the total number of head-dips did not differ from wild-type (J:182220)
• mutants show a tendency to perform consecutive head-dips of more than 4 repetitions, a behavior not seen in wild-type mice (J:182220)
• however, mutants do not exhibit spontaneous stereotypic behavior such as jumping, circling, paw flapping or self-grooming (J:182220)
• in the hot plate test, mutants exhibit shorter latency to respond to thermal stimuli indicating sensory hypersensitivity (J:182220)
• in the hot plate test, mutants exhibit shorter latency to respond to thermal stimuli indicating sensory hypersensitivity (J:182220)
• mutants exhibit reduced nest-building activity (J:182220)
• mutants exhibit reduced nest-building activity (J:182220)
• in a separation-reunion test with siblings, mutants show less interactions with siblings after reunion (J:182220)
• in the resident-intruder test, while wild-type mice explore the intruder extensively, mutants seldom chase the intruder and instead frequently show behaviors of avoidance, such as freezing and moving away (J:182220)
• in the social dominance tube test, mutants almost always retreat out of the tube and lose (J:182220)
• in a separation-reunion test with siblings, mutants show less interactions with siblings after reunion (J:182220)
• in the resident-intruder test, while wild-type mice explore the intruder extensively, mutants seldom chase the intruder and instead frequently show behaviors of avoidance, such as freezing and moving away (J:182220)
• in the social dominance tube test, mutants almost always retreat out of the tube and lose (J:182220)
• ultrasonic vocalization emitted by mutants is reduced significantly in terms of number, duration, and amplitude of calls in response to female odor compared to wild-type mice (J:182220)
• complexity of ultrasonic vocalization is reduced compared to wild-type mice (J:182220)
• ultrasonic vocalization emitted by mutants is reduced significantly in terms of number, duration, and amplitude of calls in response to female odor compared to wild-type mice (J:182220)
• complexity of ultrasonic vocalization is reduced compared to wild-type mice (J:182220)

integument
• in the hot plate test, mutants exhibit shorter latency to respond to thermal stimuli indicating sensory hypersensitivity (J:182220)
• in the hot plate test, mutants exhibit shorter latency to respond to thermal stimuli indicating sensory hypersensitivity (J:182220)

nervous system
• excitatory synaptic transmission is altered in amygdala neurons (J:182220)
• however, mutants do not exhibit overt abnormalities in the overall morphology of the amygdala or in the morphology of dendritic arbors and spines in pyramidal neurons of the basolateral amygdala (J:182220)
• excitatory synaptic transmission is altered in amygdala neurons (J:182220)
• however, mutants do not exhibit overt abnormalities in the overall morphology of the amygdala or in the morphology of dendritic arbors and spines in pyramidal neurons of the basolateral amygdala (J:182220)
• mutants exhibit depressed input-output curve of compound excitatory postsynaptic currents (EPSCs) in the basolateral amygdala (J:182220)
• mutants exhibit depressed input-output curve of compound excitatory postsynaptic currents (EPSCs) in the basolateral amygdala (J:182220)
• mutants exhibit reduced AMPA receptor-mediated synaptic strength in basolateral amygdala neurons (J:182220)
• mutants exhibit reduced AMPA receptor-mediated synaptic strength in basolateral amygdala neurons (J:182220)
• frequency of mEPSCs is reduced in mutant basolateral amygdala pyramidal neurons (J:182220)
• amplitude of mEPSCs is reduced in basolateral amygdala neurons, indicating that AMPA receptor-mediated postsynaptic activity is reduced (J:182220)
• however, neither the rising nor the decay of time of mEPSCs is altered, indicating that channel kinetics of AMPA receptors is preserved (J:182220)
• frequency of mEPSCs is reduced in mutant basolateral amygdala pyramidal neurons (J:182220)
• amplitude of mEPSCs is reduced in basolateral amygdala neurons, indicating that AMPA receptor-mediated postsynaptic activity is reduced (J:182220)
• however, neither the rising nor the decay of time of mEPSCs is altered, indicating that channel kinetics of AMPA receptors is preserved (J:182220)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:180302


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory