Mouse Genome Informatics
hm
    Tyrc-h/Tyrc-h
B6.Cg-Tyrc-h/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
pigmentation
• the first coat is a uniform light tan
• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark
• mutants treated with nitisinone show increased pigmentation in areas of new hair growth
• mutants exhibit iris transillumination that is not observed in wild-type mice
• mutants treated with nitisinone show increased pigmentation in the irides
• eyes are minimally pigmented and appear red

integument
• the first coat is a uniform light tan
• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark
• mutants treated with nitisinone show increased pigmentation in areas of new hair growth

vision/eye
• mutants exhibit iris transillumination that is not observed in wild-type mice
• mutants treated with nitisinone show increased pigmentation in the irides
• eyes are minimally pigmented and appear red

Mouse Models of Human Disease
OMIM IDRef(s)
Albinism, Oculocutaneous, Type IB; OCA1B 606952 J:178454