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Phenotypes Associated with This Genotype
Genotype
MGI:5316479
Allelic
Composition
Tyrc-h/Tyrc-h
Genetic
Background
B6.Cg-Tyrc-h/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-h mutation (2 available); any Tyr mutation (357 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the first coat is a uniform light tan
• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark
• mutants treated with nitisinone show increased pigmentation in areas of new hair growth
• mutants exhibit iris transillumination that is not observed in wild-type mice
• mutants treated with nitisinone show increased pigmentation in the irides
• eyes are minimally pigmented and appear red

integument
• the first coat is a uniform light tan
• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark
• mutants treated with nitisinone show increased pigmentation in areas of new hair growth

vision/eye
• mutants exhibit iris transillumination that is not observed in wild-type mice
• mutants treated with nitisinone show increased pigmentation in the irides
• eyes are minimally pigmented and appear red

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
oculocutaneous albinism DOID:0050632 OMIM:PS203100
J:178454


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory