Phenotypes Associated with This Genotype

Genotype
MGI:5316087

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Notch1)Dam}/Gt(ROSA)26Sor⁺; Tg(Wt1-cre)#Jbeb/0
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development ( J:178290 )

• mice die at E15.5

cardiovascular system

thin myocardium compact layer ( J:178290 )

• reduced subepicardium thickness is detected at E14.5

hemopericardium ( J:178290 )

• death is associated with pericardial bleeding (suggesting cardiac failure as cause of death)

abnormal epicardium morphology ( J:178290 )

• gaps in epicardium are usually associated with cysts and epicardial blistering

homeostasis/metabolism

hemopericardium ( J:178290 )

• death is associated with pericardial bleeding (suggesting cardiac failure as cause of death)

muscle

thin myocardium compact layer ( J:178290 )

• reduced subepicardium thickness is detected at E14.5