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Phenotypes Associated with This Genotype
Genotype
MGI:5316081
Allelic
Composition		 Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh/Gt(ROSA)26Sor+
Tg(NPHS2-icre/ERT2)1Dnsh/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
Tg(NPHS2-icre/ERT2)1Dnsh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
albuminuria ( J:182287 )
• following 2 and 5 weeks of tamoxifen treatment
abnormal podocyte foot process morphology ( J:182287 )
• tamoxifen-treated mice exhibit reduced numbers of podocytes compared with wild-type mice
podocyte foot process effacement ( J:182287 )
• tamoxifen-treated mice exhibit reduced numbers of podocytes compared with wild-type mice
expanded mesangial matrix ( J:182287 )
• in some mice 5 weeks after induction with tamoxifen

homeostasis/metabolism
albuminuria ( J:182287 )
• following 2 and 5 weeks of tamoxifen treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory