Phenotypes Associated with This Genotype

Genotype
MGI:5316005

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-COX8A/PstI*)1Ctm/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:145737 )

• mutants grown in the presence of Dox from E0 to P21 become progressively less active after the removal of Dox and die before 100 days of age

behavior/neurological

limb grasping ( J:145737 )

• mutants grown in the absence of Dox develop an abnormal limb-clasping behavior at 2 months of age

• mutants grown in the presence of Dox from E0 to P21, however, do not exhibit this limb-clasping behavior

decreased locomotor activity ( J:145737 )

• mutants grown in the presence of Dox from E0 to P21 become progressively less active after the removal of Dox and die before 100 days of age