Phenotypes Associated with This Genotype

Genotype
MGI:5315770

• Allelic Composition: Tnrc6a^Gt(XE786)Byg/Tnrc6a^Gt(XE786)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Embryonic lethality and yolk sac defects in Tnrc6a^Gt(XE786)Byg/Tnrc6a^Gt(XE786)Byg mice

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:182447 )

• most mice mice die between E9.5 and E12.5

hematopoietic system

impaired hematopoiesis ( J:182447 )

decreased hematopoietic cell number ( J:182447 )

• in the yolk sac

decreased erythrocyte cell number ( J:182447 )

• at E9.5

embryo

abnormal visceral yolk sac blood island morphology ( J:182447 )

• blood islands are smaller with fewer hematopoietic cells compared to in wild-type mice

abnormal extraembryonic endoderm formation ( J:182447 )

• thin endoderm layer in the yolk sac at E9.5

integument

pallor ( J:182447 )

• pale at E9.5

cellular

decreased cell proliferation ( J:182447 )

• in the yolk sac endoderm and mesoderm