Phenotypes Associated with This Genotype

Genotype
MGI:5315765

• Allelic Composition: Bhlhe22^tm1Meg/Bhlhe22^tm1Meg
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:182304 )

N • mice exhibit normal cortical layering

abnormal axon guidance ( J:182304 )

• axons from corticospinal motor neurons terminal prematurely and fail to enter the spinal cord unlike in wild-type mice

absent corpus callosum ( J:182304 )

absent hippocampal commissure ( J:182304 )

absent anterior commissure ( J:182304 )

abnormal anterior corticospinal tract morphology ( J:182304 )

• mice exhibit a reduction of the corticospinal tract compared with wild-type mice

behavior/neurological

excessive scratching ( J:182304 )

• resulting in skin lesions at 6 weeks of age

abnormal motor coordination/balance ( J:182304 )

• a few mice exhibit a handstand phenotype (walking on forepaws) secondary to hindpaw contraction

integument

skin lesions ( J:182304 )

• due to excessive scratching at 6 weeks of age

cellular

abnormal axon guidance ( J:182304 )

• axons from corticospinal motor neurons terminal prematurely and fail to enter the spinal cord unlike in wild-type mice