mortality/aging
• do not survive to term and most die by E15.5
|
craniofacial
• more severe facial malformations than in Ror2tm1.2Meg single homozygotes
|
limbs/digits/tail
short limbs
(
J:182150
)
• more severe truncation of the limbs than in Ror2tm1.2Meg single homozygotes
|
embryo
• more severe than in Ror2tm1.2Meg single homozygotes
|
homeostasis/metabolism
• edema in the trunk
|
nervous system
exencephaly
(
J:182150
)
• occasional
|
growth/size/body
• more severe facial malformations than in Ror2tm1.2Meg single homozygotes
|