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Phenotypes Associated with This Genotype
Genotype
MGI:5315430
Allelic
Composition
Tg(Myh6-MYL2*A13T)L1Dsc/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• enlarged interventricular septa
• mutants exhibit a decrease in the number of nuclei/mm2 in hearts, indicating hypertrophy leading to an increase in the size of myocytes
• mutants exhibit fibrotic lesions in left ventricular walls
• increase in isometric force production and a 25% decrease in Vmax of the acto-myosin ATPase, however no change in the force-pCa relationship
• 1.4-fold increase in maximal contractile force

muscle

Mouse Models of Human Disease
OMIM ID Ref(s)
Cardiomyopathy, Familial Hypertrophic, 10; CMH10 608758 J:181028


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory