Mouse Genome Informatics
tg
    Tg(Myh6-MYL2*A13T)L1Dsc/0
involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• enlarged interventricular septa
• mutants exhibit a decrease in the number of nuclei/mm2 in hearts, indicating hypertrophy leading to an increase in the size of myocytes
• mutants exhibit fibrotic lesions in left ventricular walls
• increase in isometric force production and a 25% decrease in Vmax of the acto-myosin ATPase, however no change in the force-pCa relationship
• 1.4-fold increase in maximal contractile force

muscle

homeostasis/metabolism
• mutants exhibit fibrotic lesions in left ventricular walls

Mouse Models of Human Disease
OMIM IDRef(s)
Cardiomyopathy, Familial Hypertrophic, 10; CMH10 608758 J:181028