About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5315001
Allelic
Composition
Tmc1baringo/Tmc1baringo
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmc1baringo mutation (0 available); any Tmc1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• at 4 weeks of age, the inner (smallest) row of stereocilia is often missing or, if present, is of irregular height
• by 8 weeks of age remaining IHCs in the basal and mid region show severe degeneration and fusion of stereocilia
• at 4 weeks of age, the inner (smallest) row of stereocilia is often missing or, if present, is of irregular height
• by 8 weeks of age lateral supporting cells show irregular morphological characteristics
• at 4 weeks of age extensive degeneration of hair and supporting cells, and the collapse of the tunnel of Corti, is evident in the basal to mid region
• severe to profound hearing loss at 4 weeks of age, ranging from 85 to 120 dB SPL

behavior/neurological
N
• no circling or head tossing/tilting behaviors are seen

nervous system
• at 4 weeks of age, the inner (smallest) row of stereocilia is often missing or, if present, is of irregular height
• by 8 weeks of age remaining IHCs in the basal and mid region show severe degeneration and fusion of stereocilia
• at 4 weeks of age, the inner (smallest) row of stereocilia is often missing or, if present, is of irregular height

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive nonsyndromic deafness 7 DOID:0110520 OMIM:600974
J:181985


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/14/2017
MGI 6.08
The Jackson Laboratory