Phenotypes Associated with This Genotype

Genotype
MGI:5314645

• Allelic Composition: Ptpn6^me/Ptpn6^me
• Genetic Background: involves: C3HeB/FeJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:72655 )

• death at around 3 weeks of age involving intra alveolar hemorrhage

growth/size/body

decreased body weight ( J:72655 )

• about half of controls

nervous system

abnormal nervous system morphology ( J:72655 )

abnormal CNS glial cell morphology ( J:72655 )

abnormal astrocyte morphology ( J:72655 )

• GFAP+ astrocytes decreased about 50% on both the hippocampus and the forebrain fiber tracts

abnormal microglial cell morphology ( J:72655 )

• F4/80+ microglial cells are reduced in number

decreased brain size ( J:72655 )

• length and width decreased

• weight normal

abnormal forebrain morphology ( J:72655 )

abnormal hippocampus development ( J:72655 )

• scattered areas of focal necrosis

abnormal telencephalon development ( J:72655 )

• scattered areas of focal necrosis in the cortex

abnormal hippocampus CA1 region morphology ( J:72655 )

• about 20% more neurons present

abnormal myelination ( J:72655 )

• decreased

respiratory system

abnormal pulmonary alveolar system morphology ( J:72655 )

• intra alveolar hemorrhage around 3 weeks of age leading to death

hematopoietic system

abnormal microglial cell morphology ( J:72655 )

• F4/80+ microglial cells are reduced in number

immune system

abnormal microglial cell morphology ( J:72655 )

• F4/80+ microglial cells are reduced in number

cellular

abnormal CNS glial cell morphology ( J:72655 )

abnormal astrocyte morphology ( J:72655 )

• GFAP+ astrocytes decreased about 50% on both the hippocampus and the forebrain fiber tracts

abnormal microglial cell morphology ( J:72655 )

• F4/80+ microglial cells are reduced in number