Phenotypes Associated with This Genotype

Genotype
MGI:5314521

• Allelic Composition: Tg(EEF1A1-Socs6)2Pwg/?
• Genetic Background: B6.129P2-Tg(EEF1A1-Socs6)2Pwg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:169366 )

• the body weight of adult mice with this transgene is ~10% greater than that of wild-type controls

homeostasis/metabolism

decreased circulating glucose level ( J:181312 )

• fasting blood glucose is lower in 2 month old mice with this transgene than in wild-type controls (80 +/- 18 mg/dl vs. 105 +/- 33 mg/dl)

decreased circulating insulin level ( J:181312 )

• fasting plasma insulin is significantly lower in mice with this transgene than in wild-type controls

• insulin levels of transgenic mice are significantly lower than those of wild-type controls 30 min after a glucose challenge

• insulin levels are lower in transgenic than in wild-type mice even when the glucose level has been clamped at 10mM for 120 min

improved glucose tolerance ( J:181312 )

• 8-10 week old mice with this transgene exhibit significantly lower plasma glucose levels than wild-type controls at all time points of a glucose tolerance test

increased insulin sensitivity ( J:181312 )

• mice with this transgene exhibit significantly greater glucose clearance than wild-type controls in an insulin tolerance test