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Phenotypes Associated with This Genotype
Genotype
MGI:5314412
Allelic
Composition
Tg(MECP2)3Hzo/0
Genetic
Background
either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MECP2)3Hzo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants exhibit anxiety-like behavior in the elevated plus maze
• mutants spend less time in the lit compartment of the light/dark box compared to wild-type mice indicating anxiety-like behavior
• mutants travel less than wild-type mice in the open field
• mutants are less interested in their familiar or novel partner mice in the partition test for social interaction and recognition

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
syndromic X-linked intellectual disability Lubs type DOID:0060799 OMIM:300260
J:181213


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory