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Phenotypes Associated with This Genotype
Genotype
MGI:5314411
Allelic
Composition
Tg(MECP2)1Hzo/0
Genetic
Background
either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MECP2)1Hzo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants exhibit anxiety-like behavior in the elevated plus maze
• mutants spend less time in the lit compartment of the light/dark box compared to wild-type mice indicating anxiety-like behavior
• mutants are less interested in their familiar or novel partner mice in the partition test for social interaction and recognition
• in the three-chamber test for sociability, mutants show a deficit in social approach behavior toward novel partner mice, without a deficit in interest toward a novel object or a deficit in activity or preference for either chamber

homeostasis/metabolism
• stress-induced corticosterone levels are higher in mutants than wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
syndromic X-linked intellectual disability Lubs type DOID:0060799 OMIM:300260
J:181213


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory