Phenotypes Associated with This Genotype

Genotype
MGI:5314238

• Allelic Composition: Syk^tm1.1Nns/Syk^tm1.1Nns; Tg(Pf4-icre)Q3Rsko/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal platelet physiology ( J:181715 )

• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets

• platelet disruption of human lymphatic endothelial cells network formation on a matrix is disrupted to a lesser extent compared to when control platelets are used

edema ( J:181715 )

• at E14.5

ascites ( J:181715 )

• around the intestine

immune system

abnormal lymphatic vessel morphology ( J:181715 )

• at E14.5, mice exhibit blood-filled vessels unlike control mice

• at 6 to 8 weeks, mice exhibit blood in mesenteric and intestinal lymphatic vessels and intestine proper unlike in control mice

• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

abnormal lymphatic vessel endothelial cell morphology ( J:181715 )

• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets

cardiovascular system

abnormal blood vessel morphology ( J:181715 )

• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

intracranial hemorrhage ( J:181715 )

• brain hemorrhages at E12.5

respiratory system

respiratory system phenotype ( J:181715 )

N • at P0, mice exhibit normal lungs

hematopoietic system

abnormal platelet physiology ( J:181715 )

• in the presence of platelets, reduced migration of lymphatic endothelial cells in a transmigration assay is weaker compared to in the presence of control platelets

• platelet disruption of human lymphatic endothelial cells network formation on a matrix is disrupted to a lesser extent compared to when control platelets are used

nervous system

intracranial hemorrhage ( J:181715 )

• brain hemorrhages at E12.5