Analysis Tools
mortality/aging
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• the 3 of 205 mice that survive up to P30 were euthanized due to deteriorating condition
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• fewer than expected mice are found at P0
• however, 3 of 205 mice survive up to P30
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• mice with respiratory distress die by P1
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cardiovascular system
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• mice exhibit a connection between the vasculature and lymphatic systems
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• in the brain (at least 1 ventricle and parenchyma) at E12.5 persisting through E18.5
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• at E12.5 persisting through E18.5
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• occasional discreet hemorrhages in the skin
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respiratory system
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• larger airways contain fluid droplets unlike in wild-type mice
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• some terminal air sacs fail to properly inflate
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• in most mice that die between birth and P1
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homeostasis/metabolism
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• abrogated
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• chylous ascites in the abdomen of newborns that survive long enough to feed
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immune system
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• between E14.5 and E18.5, mice exhibit blood-filled lymphatic vessels in the skin unlike in wild-type mice
• at P0, lymphatic vessels in the lungs contain blood cells unlike in wild-type mice
• mice exhibit a connection between the vasculature and lymphatic systems
• when fetal livers are used to reconstitute irradiated wild-type mice, chimeras exhibit loss of lymphatic vessel integrity compared with wild-type mice
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• at E16.5, E18.5 and P0, the ratio of lymphatic endothelial cells to blood endothelial cells is reduced in the mesenteric vessels surrounding the intestine, the intestine proper and lungs compared to in wild-type mice
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nervous system
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• mice exhibit a connection between the vasculature and lymphatic systems
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• in the brain (at least 1 ventricle and parenchyma) at E12.5 persisting through E18.5
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• at E12.5 persisting through E18.5
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integument
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• occasional discreet hemorrhages in the skin
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hematopoietic system
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• abrogated
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