Phenotypes Associated with This Genotype

Genotype
MGI:5313530

• Allelic Composition: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
• Genetic Background: C57BL/6-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:180835 )

• newly formed plaques and preexisting plaques grow at similar rates

• mutants develop amyloid plaques over time that increase in size, with the highest rate of new plaque appearance in mice between 4 and 5 months of age

homeostasis/metabolism

amyloid beta deposits ( J:180835 )

• mutants develop amyloid plaques over time that increase in size, with the highest rate of new plaque appearance in mice between 4 and 5 months of age

• newly formed plaques and preexisting plaques grow at similar rates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652	OMIM:104300 OMIM:502500 OMIM:604154 OMIM:608907	J:180835