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Phenotypes Associated with This Genotype
Genotype
MGI:5313510
Allelic
Composition
Tg(CRYBB1-CRYGC*)#Jfhe/?
Genetic
Background
involves: FVB/N
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No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• lenses appear normal at P8, however by P21, lens fiber cells show variable degrees of degeneration, with small vacuoles appearing in the equatorial epithelial cells and superficial cortical fiber cells (J:181433)
• by 6 weeks of age, all lenses exhibit abnormalities comprising of large vacuoles in cortical fiber cells and swollen nucleated fiber cells (bladder cells) with protein-filled lacunae (J:181433)
• the fiber cell migration and elongation patter is defective at the equatorial region (J:181433)
• the fiber cell migration and elongation patter is defective at the equatorial region (J:181433)
• lenses appear normal at P8, however by P21, lens fiber cells show variable degrees of degeneration, with small vacuoles appearing in the equatorial epithelial cells and superficial cortical fiber cells (J:181433)
• by 6 weeks of age, all lenses exhibit abnormalities comprising of large vacuoles in cortical fiber cells and swollen nucleated fiber cells (bladder cells) with protein-filled lacunae (J:181433)
• mutants exhibit nuclear cataracts of varying severities (J:181433)
• mutants exhibit nuclear cataracts of varying severities (J:181433)

Mouse Models of Human Disease
OMIM ID Ref(s)
Cataract 2, Multiple Types; CTRCT2 604307 J:181433


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory