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Phenotypes Associated with This Genotype
Genotype
MGI:5313510
Allelic
Composition
Tg(CRYBB1-CRYGC*)#Jfhe/?
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• lenses appear normal at P8, however by P21, lens fiber cells show variable degrees of degeneration, with small vacuoles appearing in the equatorial epithelial cells and superficial cortical fiber cells
• by 6 weeks of age, all lenses exhibit abnormalities comprising of large vacuoles in cortical fiber cells and swollen nucleated fiber cells (bladder cells) with protein-filled lacunae
• the fiber cell migration and elongation patter is defective at the equatorial region
• mutants exhibit nuclear cataracts of varying severities

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cataract 2 multiple types DOID:0110235 OMIM:604307
J:181433


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory