Phenotypes Associated with This Genotype

Genotype
MGI:5313436

• Allelic Composition: Becn1^tm1Blev/Becn1⁺; Tg(CAG-EGFP/Map1lc3b)53Nmz/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired autophagy ( J:181308 )

• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles

homeostasis/metabolism

impaired exercise endurance ( J:181308 )

• mice exhibit decreased maximal treadmill running distance compared with wild-type mice

impaired autophagy ( J:181308 )

• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles

behavior/neurological

impaired exercise endurance ( J:181308 )

• mice exhibit decreased maximal treadmill running distance compared with wild-type mice