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Phenotypes Associated with This Genotype
Genotype
MGI:5313436
Allelic
Composition		 Becn1tm1Blev/Becn1+
Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6NCrj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1tm1Blev mutation (1 available); any Becn1 mutation (35 available)
Tg(CAG-EGFP/Map1lc3b)53Nmz mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
impaired autophagy ( J:181308 )
• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles

homeostasis/metabolism
impaired exercise endurance ( J:181308 )
• mice exhibit decreased maximal treadmill running distance compared with wild-type mice
impaired autophagy ( J:181308 )
• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles

behavior/neurological
impaired exercise endurance ( J:181308 )
• mice exhibit decreased maximal treadmill running distance compared with wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory