Phenotypes Associated with This Genotype

Genotype
MGI:5313413

• Allelic Composition: Mamstr^tm1.2Eno/Mamstr^tm1.2Eno; Mrtfa^tm1Eno/Mrtfa^tm1Eno
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:179880 )

• about 40% die perinatally

muscle

decreased skeletal muscle weight ( J:179880 )

• in mice that survive past P1

muscular atrophy ( J:179880 )

• dramatic muscle wasting at 44 weeks of age

abnormal muscle physiology ( J:179880 )

• failure of satellite cell differentiation

abnormal skeletal muscle satellite cell proliferation ( J:179880 )

• hyperproliferative in culture

impaired skeletal muscle regeneration ( J:179880 )

• complete absence of myofiber regeneration at 7 days post cardiotoxin induced muscle injury

cellular

abnormal skeletal muscle satellite cell proliferation ( J:179880 )

• hyperproliferative in culture

growth/size/body

decreased body weight ( J:179880 )

• in mice that survive past P1

cachexia ( J:179880 )

• dramatic muscle wasting at 44 weeks of age