Phenotypes Associated with This Genotype

Genotype
MGI:5313388

• Allelic Composition: Rr17^tm1.1Cdon/Rr17^tm1.1Cdon
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:181186 )

N • T cells exhibit normal Th1, Th2, and induced T regulatory cell differentiation

decreased interleukin-17 secretion ( J:181186 )

• of IL17A and IL17F in Th17-polarized T cells

• of IL17A in the gamma delta or lymphoid tissue inducer cells, laminal propria cells and intestinal intraepithelial lymphocytes

• of IL17A and to a lesser extent IL17F in splenocytes from mice treated with MOG33-55 to induce experimental autoimmune encephalomyelitis

increased interleukin-17 secretion ( J:181186 )

• of IL17F in the gamma delta, lymphoid tissue inducer cells, laminal propria cells and intestinal intraepithelial lymphocytes

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:181186 )

• resistant with 3 of 5 mice recovering unlike wild-type mice