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Phenotypes Associated with This Genotype
Genotype
MGI:5312905
Allelic
Composition		 Mirc33tm1Bdes/Mirc33tm1Bdes
Genetic
Background		 Not Specified
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal thymus involution ( J:180783 )
• premature involution starting after 4 weeks of age
• chemical castration, transplantation of wild-type bone marrow into mutants, or transplantation of mutant thymi into wild-type mice fails to reverse involution
• unlike in wild-type mice, a low dose of poly I:C induces rapid involution

immune system
abnormal thymus involution ( J:180783 )
• premature involution starting after 4 weeks of age
• chemical castration, transplantation of wild-type bone marrow into mutants, or transplantation of mutant thymi into wild-type mice fails to reverse involution
• unlike in wild-type mice, a low dose of poly I:C induces rapid involution

endocrine/exocrine glands
abnormal thymus involution ( J:180783 )
• premature involution starting after 4 weeks of age
• chemical castration, transplantation of wild-type bone marrow into mutants, or transplantation of mutant thymi into wild-type mice fails to reverse involution
• unlike in wild-type mice, a low dose of poly I:C induces rapid involution

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory