Phenotypes Associated with This Genotype

Genotype
MGI:5312325

• Allelic Composition: Dcc^tm1.1Mehl/Dcc^tm1.1Mehl
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased fibroblast apoptosis ( J:181517 )

• MEFs in culture do not undergo apoptosis as readily as do controls when serum is removed

decreased enterocyte apoptosis ( J:181517 )

• less apoptosis in intestinal epithelium while cell proliferation and differentiation are normal

digestive/alimentary system

digestive/alimentary phenotype ( J:181517 )

N • overall organization of the intestinal epithelium is unaffected

decreased enterocyte apoptosis ( J:181517 )

• less apoptosis in intestinal epithelium while cell proliferation and differentiation are normal

increased intestinal adenocarcinoma incidence ( J:181517 )

• spontaneous neoplastic transformations in 14.8% of homozygotes

• including adenocarcinomas

increased intestinal adenoma incidence ( J:181517 )

• spontaneous neoplastic transformations in 14.8% of homozygotes

• including adenomas

neoplasm

increased intestinal adenocarcinoma incidence ( J:181517 )

• spontaneous neoplastic transformations in 14.8% of homozygotes

• including adenocarcinomas

increased intestinal adenoma incidence ( J:181517 )

• spontaneous neoplastic transformations in 14.8% of homozygotes

• including adenomas