Phenotypes Associated with This Genotype

Genotype
MGI:5311855

• Allelic Composition: Ift140^{tm1b(KOMP)Wtsi}/Ift140^{tm1c(KOMP)Wtsi}; Tg(Hoxb7-cre)13Amc/?
• Genetic Background: B6J.B6-Ift140^{tm1b(KOMP)Wtsi}/Ift140^{tm1c(Komp)Wtsi} Tg(Hoxb7-cre)13Amc
• Cell Lines: EPD0073_5_F01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney morphology ( J:181533 )

decreased kidney epithelial cell primary cilium length ( J:181533 )

• either very short or no cilia are present in collecting ducts at birth

• cilia continue to be present in decreasing numbers at 10 and 20 days of age

kidney cyst ( J:181533 )

• extensive cysts throughout the kidney by 20 days of age

kidney cortex cyst ( J:181533 )

• present at 10 days of age

kidney medulla cyst ( J:181533 )

• present at 5 and 10 days of age

abnormal kidney collecting duct morphology ( J:181533 )

• only very short cilia are assembled

dilated kidney collecting duct ( J:181533 )

• at birth

• stumpy cilia present at at 10 and 20 days of age

renal fibrosis ( J:181533 )

• cystic kidneys are fibrotic

• increased interstitial cell smooth muscle actin

• increased collagen

abnormal kidney physiology ( J:181533 )

increased kidney apoptosis ( J:181533 )

• at 20 days of age in non-collecting duct cells

increased kidney cell proliferation ( J:181533 )

• percentage of mitotic cells is elevated and remains high in collecting ducts

kidney failure ( J:181533 )

• during the third week of life

cellular

cellular phenotype ( J:181533 )

N • normal orientation of mitotic spindles in precystic collecting ducts of the kidney

decreased kidney epithelial cell primary cilium length ( J:181533 )

• either very short or no cilia are present in collecting ducts at birth

• cilia continue to be present in decreasing numbers at 10 and 20 days of age

increased kidney apoptosis ( J:181533 )

• at 20 days of age in non-collecting duct cells

increased kidney cell proliferation ( J:181533 )

• percentage of mitotic cells is elevated and remains high in collecting ducts

growth/size/body

kidney cyst ( J:181533 )

• extensive cysts throughout the kidney by 20 days of age

kidney cortex cyst ( J:181533 )

• present at 10 days of age

kidney medulla cyst ( J:181533 )

• present at 5 and 10 days of age