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Phenotypes Associated with This Genotype
Genotype
MGI:5309018
Allelic
Composition		 Lair1tm1Jco/Lair1tm1Jco
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lair1tm1Jco mutation (1 available); any Lair1 mutation (34 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG2a level ( J:180203 )
• significant decrease in IgG2a levels in response to TNP-OVA immunization as compared to control
decreased IgG2b level ( J:180203 )
• significant decrease in IgG2b levels in response to TNP-OVA immunization as compared to control

hematopoietic system
decreased IgG2a level ( J:180203 )
• significant decrease in IgG2a levels in response to TNP-OVA immunization as compared to control
decreased IgG2b level ( J:180203 )
• significant decrease in IgG2b levels in response to TNP-OVA immunization as compared to control

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory