Phenotypes Associated with This Genotype

Genotype
MGI:5309016

• Allelic Composition: Ncr1^noe/Ncr1^noe
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:179728 )

• mice survive infection with intermediate doses of MCMV unlike wild-type mice

• mice survive longer following infection with high doses of MCMV compared to wild-type mice

• more resistant to H1N1PR8 infection associated with an increase frequency of IFNG producing NK cells in the lungs

immune system

increased NK cell number ( J:179728 )

• increase in the frequency of IFNG producing NK cells in the lungs 2 -3 days after H1N1PR8 infection

decreased CD4-positive, alpha-beta T cell number ( J:179728 )

• decrease in the frequency of IFNG producing CD4+ cells following MCMV infection

decreased CD8-positive, alpha-beta T cell number ( J:179728 )

• decrease in the number of CD8+ T cells specific for the immunodominant MCMV peptide m45 presented by H-2D^b in the spleen at 7 and 10 days after MCMV infection

• decrease in the frequency of IFNG producing CD8+ cells following MCMV infection

decreased CD8-positive, alpha-beta memory T cell number ( J:179728 )

• following rechallenge with Listeria monocytogenes expressing ovalbumin (Lm-OVA) the percentage of memory Lm-OVA specific CD8+ cells is reduced

abnormal NK cell physiology ( J:179728 )

• cultured cells are hyperreactive in response to the prototypic NK cell tumor target cell line, YAC-1, and following stimulation by monoclonal antibody cross-linking to the activating receptor

• in culture stimulated cells are less sensitive to the phosphatidylinositol 3-kinase inhibitor wortmannin

increased susceptibility to bacterial infection ( J:179728 )

• following rechallenge with Lm-OVA the bacterial load in the spleen is elevated compared to wild-type mice

decreased susceptibility to Herpesvirales infection ( J:179728 )

• 4 days after infection with MCMV, viral loads are lower in the spleen and liver compared to wild-type controls

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:179728 )

• mice survive infection with intermediate doses of MCMV unlike wild-type mice

• mice survive longer following infection with high doses of MCMV compared to wild-type mice

• more resistant to H1N1PR8 infection associated with an increase frequency of IFNG producing NK cells in the lungs

hematopoietic system

increased NK cell number ( J:179728 )

• increase in the frequency of IFNG producing NK cells in the lungs 2 -3 days after H1N1PR8 infection

decreased CD4-positive, alpha-beta T cell number ( J:179728 )

• decrease in the frequency of IFNG producing CD4+ cells following MCMV infection

decreased CD8-positive, alpha-beta T cell number ( J:179728 )

• decrease in the number of CD8+ T cells specific for the immunodominant MCMV peptide m45 presented by H-2D^b in the spleen at 7 and 10 days after MCMV infection

• decrease in the frequency of IFNG producing CD8+ cells following MCMV infection

decreased CD8-positive, alpha-beta memory T cell number ( J:179728 )

• following rechallenge with Listeria monocytogenes expressing ovalbumin (Lm-OVA) the percentage of memory Lm-OVA specific CD8+ cells is reduced

abnormal NK cell physiology ( J:179728 )

• cultured cells are hyperreactive in response to the prototypic NK cell tumor target cell line, YAC-1, and following stimulation by monoclonal antibody cross-linking to the activating receptor

• in culture stimulated cells are less sensitive to the phosphatidylinositol 3-kinase inhibitor wortmannin