Phenotypes Associated with This Genotype

Genotype
MGI:5308972

• Allelic Composition: Cdx2^tm2Fbe/Cdx2^tm2Fbe; Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:179732 )

• by 6 weeks after treatment cystic vesicles persist and are often filled with mucous and detritus

increased Paneth cell number ( J:179732 )

• an excess of Paneth cells are found by 19-62 weeks after treatment and these cells contain an abnormally abundant number of normal looking secretory granules

abnormal intestine physiology ( J:179732 )

• 4 weeks after treatment with tamoxifen a low level of excess mucous secretion is seen

abnormal Paneth cell physiology ( J:179732 )

• by 6 weeks after treatment dying Paneth cells are commonly seen

cellular

abnormal cell migration ( J:179732 )

• recombined cells fail to migrate out of the crypts and up the villi in the intestine

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:179732 )

• by 6 weeks after treatment cystic vesicles persist and are often filled with mucous and detritus

increased Paneth cell number ( J:179732 )

• an excess of Paneth cells are found by 19-62 weeks after treatment and these cells contain an abnormally abundant number of normal looking secretory granules