Phenotypes for Ctnnb1 MGI:5308949 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ctnnb1^tm2Kba/Ctnnb1^tm2Kba
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kba mutation (0 available); any Ctnnb1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:178971 )

• total failure of embryonic development at E7.5

embryo

abnormal gastrulation ( J:178971 )

• strong defects in gastrulation are visible at E7.5

• the majority of cells detached from the ectodermal cell layer and compact uniform cell masses formed without any signs of mesoderm or other defined germ layers

absent mesoderm ( J:178971 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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