Phenotypes Associated with This Genotype

Genotype
MGI:5308815

• Allelic Composition: Tuba1a^Rgsc1736/Tuba1a⁺
• Genetic Background: C3.B6-Tuba1a^Rgsc1736

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:180670 )

• more time spent in the center in an open field test

abnormal response to novel object ( J:180670 )

• reduced time spent exploring a novel object

increased locomotor activity ( J:180670 )

• more locomotor activity in an open field test

nervous system

abnormal neuron morphology ( J:180670 )

• BrdU labeled neocortical neurons are more broadly distributed than in controls at E13

abnormal cerebral cortex pyramidal cell morphology ( J:180670 )

• stratification of layers III-V of pyramidal cells in the neocortex is disorganized

• arrangement of microtubules in dendrites of neocortical pyramidal neurons is disorganized

abnormal dendrite morphology ( J:180670 )

• arrangement of microtubules in dendrites of neocortical pyramidal neurons is disorganized