Phenotypes Associated with This Genotype

Genotype
MGI:5308775

• Allelic Composition: Akap13^tm1Segj/Akap13⁺
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced fertility ( J:181087 )

immune system

increased transitional stage T1 B cell number ( J:181088 )

• in the spleen

decreased B cell number ( J:181088 )

• decreased CD19+/CD21+ B cells in the spleen

decreased transitional stage T2 B cell number ( J:181088 )

• in the spleen

small spleen ( J:181088 )

decreased spleen weight ( J:181088 )

• in male and female mice

spleen hypoplasia ( J:181088 )

decreased spleen B cell follicle size ( J:181088 )

• smaller than in wild-type mice

decreased splenocyte number ( J:181088 )

abnormal lymphocyte physiology ( J:111574 )

• lymphocytes exhibit decreased glucocorticoid sensitivity compared with wild-type cells

decreased IgG1 level ( J:181088 )

• in response to ovalbumin

abnormal splenocyte physiology ( J:181088 )

• splenocytes exhibit impaired gene expression response to osmotic stress compared with wild-type cells

hematopoietic system

increased transitional stage T1 B cell number ( J:181088 )

• in the spleen

decreased B cell number ( J:181088 )

• decreased CD19+/CD21+ B cells in the spleen

decreased transitional stage T2 B cell number ( J:181088 )

• in the spleen

small spleen ( J:181088 )

decreased spleen weight ( J:181088 )

• in male and female mice

spleen hypoplasia ( J:181088 )

decreased spleen B cell follicle size ( J:181088 )

• smaller than in wild-type mice

decreased splenocyte number ( J:181088 )

abnormal lymphocyte physiology ( J:111574 )

• lymphocytes exhibit decreased glucocorticoid sensitivity compared with wild-type cells

decreased IgG1 level ( J:181088 )

• in response to ovalbumin

abnormal splenocyte physiology ( J:181088 )

• splenocytes exhibit impaired gene expression response to osmotic stress compared with wild-type cells