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Phenotypes Associated with This Genotype
Genotype
MGI:5308205
Allelic
Composition
GarsNmf249/Gars+
Genetic
Background
involves: C57BL/6J * CAST/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GarsNmf249 mutation (1 available); any Gars mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

nervous system
• size of the femoral nerve is reduced
• 26% reduction in axons in motor nerves
• partially denervated neuromuscular junctions
• motor and sensory branches of the femoral nerve have a reduction in myelinated axon numbers
• nerve conduction is reduced to about 25% of wild-type velocities

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Charcot-Marie-Tooth disease type 2D DOID:0110164 OMIM:601472
J:179811


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory