Phenotypes Associated with This Genotype

Genotype
MGI:5307043

• Allelic Composition: Card11^tm1.1Litt/Card11^tm1.1Litt; Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:180410 )

N • memory T cell development is unaffected

abnormal T cell activation ( J:180410 )

• impaired "reactivation" of T cells after a second antibody challenge

respiratory system inflammation ( J:180410 )

• decreased cellular infiltration of lungs when rechallenged 6 weeks after initial Ova exposure

• fewer cells in bronchoalveolar lavage fluid

• fewer eosinophiles

• increased number of macrophage

• reduced number of activated T cells after rechallenge (CD4+CD69+)

respiratory system

respiratory system phenotype ( J:180410 )

N • acute airway response to Ova challenge is unaffected

respiratory system inflammation ( J:180410 )

• decreased cellular infiltration of lungs when rechallenged 6 weeks after initial Ova exposure

• fewer cells in bronchoalveolar lavage fluid

• fewer eosinophiles

• increased number of macrophage

• reduced number of activated T cells after rechallenge (CD4+CD69+)

hematopoietic system

abnormal T cell activation ( J:180410 )

• impaired "reactivation" of T cells after a second antibody challenge