Phenotypes Associated with This Genotype

Genotype
MGI:5306893

• Allelic Composition: Casr^tm1Wch/Casr^tm1Wch; Tg(Col2a1-cre)1Bhr/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:180651 )

• no mice are detected between E14 and E16

embryonic lethality during organogenesis, incomplete penetrance ( J:180651 )

• only 2 mice are detected between E12 and E13

skeleton

abnormal skeleton development ( J:180651 )

• at E12.5, the two surviving mice exhibit short skeletons compared with control mice

decreased bone mineralization ( J:180651 )

• mice exhibit poorly mineralized rib cages, calvariae, and long bones compared with control mice