Phenotypes Associated with This Genotype

Genotype
MGI:5306891

• Allelic Composition: Casr^tm1Wch/Casr^tm1Wch; Tg(Col1a1-cre)2Bek/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:180651 )

• mice die within 3 weeks of birth

skeleton

abnormal skeleton morphology ( J:180651 )

• small, fragile, and undermineralized skeleton

decreased bone mineral density ( J:180651 )

decreased compact bone volume ( J:180651 )

decreased compact bone thickness ( J:180651 )

abnormal trabecular bone morphology ( J:180651 )

• mice exhibit increased trabecular spacing compared with control mice

decreased trabecular bone volume ( J:180651 )

decreased bone trabecula number ( J:180651 )

decreased trabecular bone connectivity density ( J:180651 )

decreased trabecular bone thickness ( J:180651 )

abnormal skeleton development ( J:180651 )

• blocked

decreased bone mineralization ( J:180651 )

• undermineralized skeleton

fragile skeleton ( J:180651 )

growth/size/body

decreased body size ( J:180651 )

• at 7 day and 21 days

decreased body weight ( J:180651 )

postnatal growth retardation ( J:180651 )

• blocked