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Phenotypes Associated with This Genotype
Genotype
MGI:5306661
Allelic
Composition		 Grhl3tm1Jane/Grhl3+
Ptentm1Mak/Pten+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3tm1Jane mutation (1 available); any Grhl3 mutation (53 available)
Ptentm1Mak mutation (1 available); any Pten mutation (86 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
increased skin papilloma incidence ( J:178952 )
• in DMBA/TPA treated mice
increased skin squamous cell carcinoma incidence ( J:178952 )
• in DMBA/TPA treated mice to a greater extent than in either single heterozygote

neoplasm
increased skin papilloma incidence ( J:178952 )
• in DMBA/TPA treated mice
increased skin squamous cell carcinoma incidence ( J:178952 )
• in DMBA/TPA treated mice to a greater extent than in either single heterozygote

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory