About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5306624
Allelic
Composition
Mecomtm1.1Miku/Mecom+
Genetic
Background
involves: C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecomtm1.1Miku mutation (0 available); any Mecom mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice exhibit an almost complete loss of long-term hematopoietic stem cells in a cell-autonomous manner compared with wild-type mice
• short-term and long-term hematopoietic stem cells self-renewal capacity is abrogated, as measured by reduced colony-forming units (granulocyte-macrophage and granulocyte-erythrocyte-monocyte-megakaryocyte progenitors) and erythroid burst-forming units, compared with wild-type cells


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory