hematopoietic system
• mice exhibit an almost complete loss of long-term hematopoietic stem cells in a cell-autonomous manner compared with wild-type mice
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• short-term and long-term hematopoietic stem cells self-renewal capacity is abrogated, as measured by reduced colony-forming units (granulocyte-macrophage and granulocyte-erythrocyte-monocyte-megakaryocyte progenitors) and erythroid burst-forming units, compared with wild-type cells
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