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Phenotypes Associated with This Genotype
Genotype
MGI:5306592
Allelic
Composition
Juntm4Wag/Juntm4Wag
Tg(Sftpc-cre)1Blh/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm4Wag mutation (0 available); any Jun mutation (4 available)
Tg(Sftpc-cre)1Blh mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mutants exhibit infiltration of atypical foamy alveolar macrophages
• mutants with prolonged exposure to cigarette smoke exhibit perivascular and peribronchiolar inflammation
• mutants exhibit an increase in apoptotic cells in the lungs
• 3 month old mutants exhibit enlarged air spaces and infiltration of atypical foamy alveolar macrophages
• progressive destruction of alveolar tissue
• mutants develop progressive emphysema
• localized destruction leading to large cavities in the parenchyma

immune system
• elevated levels of IL-12p40, IL-13, and CXCL1 cytokines in the BAL
• an elevated level of TNF-alpha is seen in the BAL fluid
• mutants exhibit infiltration of atypical foamy alveolar macrophages
• mutants with prolonged exposure to cigarette smoke exhibit perivascular and peribronchiolar inflammation

homeostasis/metabolism
• elevated levels of IL-12p40, IL-13, and CXCL1 cytokines in the BAL
• an elevated level of TNF-alpha is seen in the BAL fluid


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory