Phenotypes for Kitl Lepr MGI:5306356 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Kitl^tm1.1Sjm/Kitl^tm2.1Sjm Lepr^tm2(cre)Rck/Lepr⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitl^tm1.1Sjm mutation (1 available); any Kitl mutation (92 available)
Kitl^tm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Lepr^tm2(cre)Rck mutation (1 available); any Lepr mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:180431 )

spleen hyperplasia ( J:180431 )

extramedullary hematopoiesis ( J:180431 )

• in the spleen

decreased hematopoietic cell number ( J:180431 )

• in the bone marrow and the spleen

• depletion in the bone marrow increases over time

immune system

enlarged spleen ( J:180431 )

spleen hyperplasia ( J:180431 )

growth/size/body

enlarged spleen ( J:180431 )

spleen hyperplasia ( J:180431 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/28/2026 MGI 6.24