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Phenotypes Associated with This Genotype
Genotype
MGI:5306350
Allelic
Composition		 Kitltm2.1Sjm/Kitltm2.1Sjm
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * C57BL/Ka * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
anemia ( J:180431 )
• in tamoxifen-treated mice
decreased bone marrow cell number ( J:180431 )
• bone marrow cells from tamoxifen-treated mice used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production (total, myeloid, T cell, and B cell)
decreased hematopoietic cell number ( J:180431 )
• in tamoxifen-treated mice
decreased erythrocyte cell number ( J:180431 )
• in tamoxifen-treated mice
abnormal bone marrow cell physiology ( J:180431 )
• bone marrow cells from tamoxifen-treated mice used to repopulate irradiated mice exhibit reduced bone marrow-derived cell production (total, myeloid, T cell, and B cell)

liver/biliary system
liver hypoplasia ( J:180431 )
• in tamoxifen-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory