Mouse Genome Informatics
cn
    Bdnftm3Jae/Bdnftm3Jae
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0

involves: 129S4/SvJae * C57BL/6 * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• life span is shorter than in Mecp2 single homozygous mice (J:106973)

behavior/neurological
• dramatic reduction in wheel running activity at 4 weeks of age (J:106973)

nervous system
• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls (J:106973)

Mouse Models of Human Disease
OMIM IDRef(s)
Rett Syndrome; RTT 312750 J:106973