Phenotypes for Bdnf Mecp2 Tg(Camk2a-cre)93Kln MGI:5306255 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bdnf^tm3Jae/Bdnf^tm3Jae Mecp2^tm1.1Jae/Y Tg(Camk2a-cre)93Kln/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnf^tm3Jae mutation (2 available); any Bdnf mutation (39 available)
Mecp2^tm1.1Jae mutation (2 available); any Mecp2 mutation (38 available)
Tg(Camk2a-cre)93Kln mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:106973 )

• life span is shorter than in Mecp2 single homozygous mice

behavior/neurological

lethargy ( J:106973 )

• dramatic reduction in wheel running activity at 4 weeks of age

nervous system

abnormal action potential ( J:106973 )

• at P30 the firing rate of layer 5 pyramidal neurons of the somatosensory cortex is reduced compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:106973

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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