Phenotypes Associated with This Genotype

Genotype
MGI:5305972

• Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enlarged spleen and lymph nodes in Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} mice

mortality/aging

premature death ( J:180054 )

• mice die within 4 months of birth

prenatal lethality, incomplete penetrance ( J:180054 )

• fewer than expected mice are born alive

• Background Sensitivity: fewer mice are born on a mixed 129P2/OlaHsd and C57BL/6 background than on a C57BL/6 congenic background

immune system

enlarged spleen ( J:180054 )

spleen hyperplasia ( J:180054 )

increased neutrophil cell number ( J:180054 )

• in the peripheral blood and spleen

increased IgA level ( J:180054 )

increased IgG1 level ( J:180054 )

increased IgG2b level ( J:180054 )

increased IgM level ( J:180054 )

enlarged lymph nodes ( J:180054 )

lymph node hyperplasia ( J:180054 )

decreased interleukin-12 secretion ( J:180054 )

• in bone marrow macrophage stimulated with CpG, R848, Pam, or LPS

decreased interleukin-12b secretion ( J:180054 )

• in bone marrow macrophage stimulated with CpG, R848, Pam, or LPS

increased susceptibility to systemic lupus erythematosus ( J:180054 )

• mice exhibit many characteristics of human SLE, including the appearance of immature granulocytes in the peripheral blood and development of autoreactive antibodies and glomerulonephritis

• bone marrow cells transplanted into irradiated mice develop inflammatory disease

• however, mice do not develop joint inflammation

increased anti-nuclear antigen antibody level ( J:180054 )

increased anti-double stranded DNA antibody level ( J:180054 )

glomerulonephritis ( J:180054 )

hematopoietic system

enlarged spleen ( J:180054 )

spleen hyperplasia ( J:180054 )

anemia ( J:180054 )

decreased hemoglobin content ( J:180054 )

increased neutrophil cell number ( J:180054 )

• in the peripheral blood and spleen

increased IgA level ( J:180054 )

increased IgG1 level ( J:180054 )

increased IgG2b level ( J:180054 )

increased IgM level ( J:180054 )

growth/size/body

decreased body size ( J:180054 )

decreased body weight ( J:180054 )

cachexia ( J:180054 )

enlarged spleen ( J:180054 )

spleen hyperplasia ( J:180054 )

renal/urinary system

increased urine protein level ( J:180054 )

glomerulonephritis ( J:180054 )

homeostasis/metabolism

increased urine protein level ( J:180054 )