Phenotypes Associated with This Genotype

Genotype
MGI:5305853

• Allelic Composition: Map3k7^tm1Aki/Map3k7^tm1Aki; Tg(Slco1c1-icre/ERT2)1Mrks/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:179050 )

N • intravenous administration of IL-1beta induces reduction in food intake (IL-1beta-induced anorexia over 22 hours; this is similar to response of control mice

lethargy ( J:179050 )

• mutants exhibit reduced lethargy relative to controls in response to intravenous IL-1beta administration

decreased locomotor activity ( J:179050 )

• injection of IL-1beta at 10 am reduced spontaneous locomotion in mutants the next night, response is weaker than in controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:179050 )

N • mice have normal body temperature

N • corticosterone plasma levels rise to same extent as controls in response to IL-1beta administration

impaired febrile response ( J:179050 )

• IL-1beta induces only a short-lasting fever response in mutants compared to controls; however, early fever response remains intact

growth/size/body

growth/size/body region phenotype ( J:179050 )

N • intravenous administration of IL-1beta induces weight loss in mutants over 22 hours; this is similar to response of control mice